洪上程
姓名 洪上程
現任 特聘研究員
所屬單位 生物化學專題中心
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02-27871279
實驗室網站
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研究方向/領域

研究方向/領域

Transcriptional and Epigenetic Regulation in Development and Disease
轉錄及表觀遺傳調控發育及疾病之機制

基因轉錄結合表觀遺傳決定細胞命運。表觀遺傳泛指一種生物機制，能夠在不改變DNA序列(genotype)的前提之下，改變基因表達及細胞表現型態(phenotype)。真核細胞的DNA，與其所纏繞的組蛋白，及其他相關蛋白，總稱為染色質。染色質調控蛋白必須修飾組蛋白或DNA，使染色質結構鬆散或緊密，DNA始能複製、轉錄或修復。染色質調控蛋白是調控表觀遺傳最重要的因子。
阮麗蓉實驗室著重於探討人類細胞中染色質調控系統蛋白的功能，其於癌變過程，早期發育，以及腦部疾病所扮演的角色。本實驗室近年研究指出，與人類發育遲緩智能不足相關的蛋白質N端乙醯酶Naa10p為胚胎DNA甲基化、基因印記及胚胎發育所需。Naa10p過量表達可導致癌症及肥胖。目前研究重點有三：
ㄧ、Naa10p於腦神經功能及病變之角色，
二、組蛋白N端加上乙醯基調控發育及疾病之機制，
三、表觀遺傳如何調控成體神經幹細胞老化。

我們期待藉這些研究發展新型藥物，治療人類疾病。
 

SELECTED PUBLICATIONS:

 

  • Yeh, F.-L., Chang, S.-L., Ahmed, G. R., Liu, H.-I, Tung, L., Yeh, C.-S., Lanier, L. S., Maeder, C., Lin, C.-M., Tsai, S.-C., Hsiao, W.-Y., Chang, W.-H., and Chang, T.-H.*, 2021, “Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling”, NATURE COMMUNICATIONS, 12, 3082. (SCIE)
  • Tsai, N.-C., Hsu, T.-S., Kuo, S.-C., Kao, C.-T., Hung, T.-H., Lin, D.-G., Yeh, C.-S., Chu, C.-C., Lin, J.-S., Lin, H.-H.; Ko, C.-Y., Chang, T.-H.*, Su, J.-C.*, and Lin, Y.-C.*, 2021, “Large-scale data analysis for robotic yeast one-hybrid platforms and multi-disciplinary studies using GateMultiplex”, BMC Biology, 19, 214. (SCIE)
  • Yeh, C.-S., Wang, Z., Miao, F., Ma, H., Kao, C.-T., Hsu, T.-S., Yu, J.-H., Hung, E.-T., Lin, C.-C., Kuan, C.-Y., Zhou, C., Qu, G.-Z., Jiang, J., Liu, G., Wang, J. P., Li, W.*, Chiang, V. L.*, Chang, T.-H.*, Lin, Y.-C. J.*, 2019, “A novel synthetic-genetic-array based yeast one-hybrid system for high discovery rate and short processing time.”, Genome Research, 29(8),1343-1351. (SCIE)
  • Chang, S.-L., Wang, H.-K., Tung, L., and Chang, T.-H.*, 2018, “Adaptive transcription-splicing resynchronization upon losing an essential splicing factor”, NATURE ECOLOGY & EVOLUTION, 2(11), 1818-1823. (SCIE)
  • Chung, C.-y., Hsiao, Y.-m., Huang, T.-Y., Chang, T.-H.*, and Chang, C-c.*, 2018, “Germline expression of the hunchback orthologues in the asexual viviparous aphids: A conserved feature within the Aphididae”, Insect Molecular Biology, 27(6), 752-765. (SCIE)
  • Chuang, T.-J., Chen, Y.-J., Chen, C.-Y., Mai, T.-L., Wang, Y.-D., Yeh, C.-S., Yang, M.-Y., Hsiao, Y.-T., Chang, T.-H., Kuo, T.-C., Cho, H.-H., Shen, C.-N., Kuo, H.-C., Lu, M.-Y., Chen, Y.-H., Hsieh, S.-C., and Chiang, T.-W., 2018, “Integrative transcriptome sequencing reveals extensive alternative trans-splicing and cis-backsplicing in human cells”, Nucleic Acids Research, 46(7), 3671-3691. (SCIE)
  • Yeh, C.-S., Chang, S.-L., Chen, J.-H., Wang, H.-K., Chou, Y.-C., Wang, C.-H., Huang, S.-H., Larson, A., Pleiss, P. A., Chang, W.-h., and Chang, T.-H.*, 2017, “The conserved AU-dinucleotide at the 5’ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex”, NUCLEIC ACIDS RESEARCH, 45 (16), 9679-9693. (SCIE)
  • Lee, F. F.-Y., Hui, C.-F., Chang, T.-H.*, Chiou, P. P.*, 2016, “Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-κB Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II”, PLOS ONE, 11(9), e0163415. (SCIE)
  • Fu-Lung Yeh, Luh Tung, and Tien-Hsien Chang*, 2016, “Detection of protein-protein interaction within an RNA-protein complex via unnatural-amino-acid-mediated photochemical crosslinking”, Methods in Molecular Biology, 1421, 175-189.
  • Chang, S. L., Leu, J.-Y.*, and Chang, T.-H.*, 2015, “A population study of killer viruses reveals different evolutionary histories of two closely related Saccharomyces sensu stricto yeasts”, Molecular Ecology, 24, 4312-4322. (SCIE)
  • Hsiang-En Hsu, Tzu-Ning Liu, Chung-Shu Yeh, Tien-Hsien Chang, Yi-Chen Lo*, and Cheng-Fu Kao*, 2015, “Feedback control of Snf1 protein and its phosphorylation is necessary for adaptation to environmental stress”, Journal of Biological Chemistry, 290, 16786-16796. (SCIE)
  • Chang, T.-H.*, Tung, L., Yeh, F.-L., Chen, J-H., and Chang, S.-L., 2013, “Functions of the DExD/H-box proteins in the nuclear pre-mRNA splicing pathway”, Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1829, 764-774. (SCIE)
  • Chang, C.-c., Hsiao, Y.-m., Huang, T.-Y., Cook, C. E., Shigenobu, S., and Chang, T.-H. , 2013, “Noncanonical expression of caudal during early embryogenesis in the pea aphid Acyrthosiphon pisum: maternal cad-driven posterior development is not conserved”, Insect Mol. Biol., 22(4), 442-455. (SCIE)
  • Wang, C.-Y., Wen, W.-L., Nilsson, D., Sunnerhagen, P., Chang, T.-H., and Wang, S.-W., 2012, “Analysis of stress granule assembly in Schizosaccharomyces pombe”, RNA, 18, 694-703. (SCIE)
  • Huang, J.-Y., Su, W.-C., Jeng, K.-S., Chang, T.-H.*, and Lai, M. M.-C.*, 2012, “Attenuation of 40S Ribosomal Subunit Abundance Differentially Affects Host and HCV Translation and Suppresses HCV Replication.”, PLoS Pathogens, 8(6), 1-14. (SCIE)
  • Shea, F. F., Rowell, J. R., Li, Y., Chang, T.-H., and Alvarez, C. E., 2012, “Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family E3 ubiquitin ligases and interact with beta arrestins.”, PLoS One, 7(12), e50557. (SCIE)
  • Shieh, G. S., Pan, C.-H,, Wu, J.-H., Sun, Y.-J., Wang, C.-C., Hsiao, W.-C., Lin, C.-Y., Tung, L., Chang, T.-H., Fleming, A. B., Hillyer, C., Lo, Y.-C., Berger, S.-L., Osley, M. A., and Kao, C.-F., 2011, “H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast”, BMC Genomics, 12, 627. (SCIE)
  • Su, C.-H., Shih, C.-H., Chang, T.-H., and Tsai, H.-K., 2010, “Genome-wide analysis of the cis-regulatory modules of divergent gene pairs in yeast.”, Genomics, 96, 352-361. (SCIE)
  • 1. Chang, L.-C., Lin, Y.-C., Tung, L., Yeh, F.-L., Yeh, C.-S., and Chang, T.-H. ，2010，〈RNA helicases: promoting the conformation changes of cellular RNAs and RNPs〉，《Chemistry》，68(4), 259-270。(Others)
  • Sung HM, Wang TY, Wang D, Huang YS, Wu JP, Tsai HK, Tzeng J, Huang CJ, Lee YC, Yang P, Hsu J, Chang T, Cho CY, Weng LC, Lee TC, Chang TH, Li WH, Shih MC, 2009, “Roles of trans and cis variation in yeast intraspecies evolution of gene expression.”, Molecular Biology and Evolution, 26(11), 2533-8. (SCIE)
  • Hage, R., Tung, L., Du, H., Stands, L., Rosbash, M., and Chang, T.-H., 2009, “A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/pre-mRNA interaction”, Molecular and Cellular Biology, 29(14), 3941-3952. (SCIE)
  • Woan-Yuh Tarn, Tien-Hsien Chang*, 2009, “The current understanding of Ded1p/DDX3 homologs from yeast to human”, RNA Biology, 6(1), 17-20. (SCIE)
  • T. Burckin, R. Nagel, Y. Mandel-Gutfreund, L. Shiue, T. Clark, J.-L. Chong, T.-H. Chang, S. Squazzo, G. Hartzog and M. Jr. Ares, 2005, “Exploring functional relationships between components of the transcription, splicing, and mRNA export machineries by gene expression phenotype analysis”, Nat. Struct. Mol. Biol, 12, 175-182. (SCIE)
  • J.-L. Chong, R.-Y. Chuang, L. Tung and T.-H. Chang, 2004, “Ded1p, a conserved DExD/H-box translation factor, can promote L-A virus negative-strand RNA synthesis in vitro”, Nucleic Acids Research, 32, 2031-2038. (SCIE)
  • S. S.-I Tseng-Rogenski, J.-L. Chong, C. B. Thomas, S. Enomoto, J. Berman and T.-H. Chang, 2003, “Functional conservation of Dhh1p, a DExD/H-box protein in Saccharomyces cerevisiae”, Nucleic Acids Research, 31, 4995-5002. (SCIE)
  • J. Y.-F. Chen, L. Stands, J. P. Staley, Jr. R. R. Jackups, L. J. Latus and T.-H. Chang*, 2001, “Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD-box splicing factor”, Molecular Cell, 7, 227-232. (SCIE)
  • S. S.-I Tseng, P. L. Weaver, Y. Liu, M. Hitomi, A. M. Tartakoff and T.-H. Chang, 1998, “A cyotosolic RNA helicase required for poly(A)+ RNA export”, EMBO J, 17, 2651-2662. (SCIE)
  • Paul L. Weaver, C. Sun, Tien-Hsien Chang* , 1997, “Dbp3p, a putative RNA helicase in Saccharomyces cerevisiae, is required for efficient pre-ribosomal RNA processing predominantly site A3”, Mol. Cell. Biol., 17(3), 1354-1365. (SCIE)
  • R.-Y. Chuang, P. L. Weaver, Z. Liu and T.-H. Chang, 1997, “Requirement of the DEAD-box protein Ded1p for messenger RNA translation”, Science, 275, 1468-1471. (SCIE)
-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors., Frontiers in Chemistry, vol. 10, 947475, 2022 -C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors., Frontiers in Chemistry, vol. 10, 947475, 2022
年度 論文名稱
2024 Chang YJ, Lin KT, Shih O, Yang CH, Chuang CY, Fang MH, Lai WB, Lee YC, Kuo HC, (Hung SC, Yao CK, Jeng US, (Chen YR, Sulfated disaccharide protects membrane and DNA damages from arginine-rich dipeptide repeats in ALS., Science advances, vol. 10(8), eadj0347, 2024
2024 Chang JL, Huang CJ, Tsai YC, Chiang NJ, Huang YS, (Hung SC)*, Shan YS*, Lee GB*, An integrated microfluidic system for automatic detection of cholangiocarcinoma cells from bile., Lab on a chip, vol. 24(2), 375-382, 2024
2023 Nguan HS, Tsai ST, Liew CY, Reddy NS, (Hung SC, Ni CK*, The collision-induced dissociation mechanism of sodiated Hex-HexNAc disaccharides., Physical chemistry chemical physics : PCCP, vol. 25(33), 22179-22194, 2023
2022 Weng WC, Liao HE, Huang SP, Tsai ST, Hsu HC, Liew CY, Gannedi V, Hung SC, Ni CK, Unusual free oligosaccharides in human bovine and caprine milk., Scientific Reports, vol. 12(1), 10790, 2022
2022 Liew CY, Hsu HC, Nguan HS, Huang YC, Zhong YQ, Hung SC, Ni CK, The Good, the Bad, and the Ugly Memories of Carbohydrate Fragments in Collision-Induced Dissociation., Journal of the American Society for Mass Spectrometry, vol. 33(10), 1891-1903, 2022
2022 Wang Chih-Hung, Chang Jia-Ru, Hung Shang-Cheng, Dou Horng-Yunn, Lee Gwo-Bin, Rapid molecular diagnosis of live Mycobacterium tuberculosis on an integrated microfluidic system, Sensors and Actuators B: Chemical, vol. 12(1), 10790, 2022
2022 Tseng KY, Tzeng ZH, Cheng TR, Liang PH, Hung SC, Design and Synthesis of 1-O- and 6
2022 Byung-sun Jeon, Teng-Yi Huang, Mark W. Ruszczycky, Sei-hyun Choi, Namho Kim, Joseph Livy Franklin, (Shang-Cheng Hung*, Hung-wen Liu*, Byproduct formation during the biosynthesis of spinosyn A and evidence for an enzymatic interplay to prevent its formation, TETRAHEDRON, vol. 103, 132569, 2022
2022 Teng KC, Tseng KY, Tzeng ZH, Hung SC, A concise synthesis of L-gulose and its C-6 derivatives., Bioorganic & Medicinal Chemistry, vol. 73, 117029, 2022
2022 Lu Tsung-Han, Chiang Nai-Jung, Tsai Yi-Cheng, Gopinathan Priya, Huang Chien-Jui, Chang Jui-Lin, Tu Hsiu-Chi, Shan Yan-Shen, Hung Shang-Cheng, Lee Gwo-Bin, An integrated microfluidic system for cholangiocarcinoma diagnosis from bile by using specific affinity probes, Sensors and Actuators B: Chemical, vol. 373, 132724, 2022
2022 Uchimura K, Nishitsuji K, Chiu LT, Ohgita T, Saito H, Allain F, Gannedi V, Wong CH, Hung SC, Design and Synthesis of 6-O-Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid beta Aggregation., Chembiochem : a European journal of chemical biology, vol. 23(15), e202200191, 2022
2022 Weng WC, Liao HE, Huang SP, Tsai ST, Hsu HC, Liew CY, Gannedi V, Ni CK, Unusual free oligosaccharides in human bovine and caprine milk., Scientific Reports, vol. 12(1), 10790, 2022
2022 Liew CY, Hsu HC, Nguan HS, Huang YC, Zhong YQ, Ni CK, The Good, the Bad, and the Ugly Memories of Carbohydrate Fragments in Collision-Induced Dissociation., Journal of the American Society for Mass Spectrometry, vol. 33(10), 1891-1903, 2022
2022 Wang Chih-Hung, Chang Jia-Ru, Hung Shang-Cheng, Dou Horng-Yunn, Lee Gwo-Bin, Rapid molecular diagnosis of live Mycobacterium tuberculosis on an integrated microfluidic system, Sensors and Actuators B: Chemical, vol. 12(1), 10790, 2022
2022 Tseng KY, Tzeng ZH, Cheng TR, Liang PH, Design and Synthesis of 1-O- and 6
2022 Byung-sun Jeon, Teng-Yi Huang, Mark W. Ruszczycky, Sei-hyun Choi, Namho Kim, Joseph Livy Franklin, (Shang-Cheng Hung*, Hung-wen Liu*, Byproduct formation during the biosynthesis of spinosyn A and evidence for an enzymatic interplay to prevent its formation, TETRAHEDRON, vol. 103, 132569, 2022
2022 Teng KC, Tseng KY, Tzeng ZH, A concise synthesis of L-gulose and its C-6 derivatives., Bioorganic & Medicinal Chemistry, vol. 73, 117029, 2022
2022 Lu Tsung-Han, Chiang Nai-Jung, Tsai Yi-Cheng, Gopinathan Priya, Huang Chien-Jui, Chang Jui-Lin, Tu Hsiu-Chi, Shan Yan-Shen, Hung Shang-Cheng, Lee Gwo-Bin, An integrated microfluidic system for cholangiocarcinoma diagnosis from bile by using specific affinity probes, Sensors and Actuators B: Chemical, vol. 373, 132724, 2022
2022 Uchimura K, Nishitsuji K, Chiu LT, Ohgita T, Saito H, Allain F, Gannedi V, Wong CH, Design and Synthesis of 6-O-Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid beta Aggregation., Chembiochem : a European journal of chemical biology, vol. 23(15), e202200191, 2022
2021 Gannedi V, Villuri BK, Reddy SN, Ku CC, Wong CH*, (Hung SC*, Practical Remdesivir Synthesis through One-Pot Organocatalyzed Asymmetric (S)-P-Phosphoramidation., The Journal of Organic Chemistry, vol. 86(7), 4977-4985, 2021
2021 Jan JT, Cheng TR, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, Cheng WC, Chein RJ, Mao SS, Liang PH, Ma C*, (Hung SC*, Wong CH*, Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection., Proceedings of the National Academy of Sciences of the United States of America, vol. 118(5), 2021
2021 Priya Gopinathan, Tsung-Han Lua, Nai-Jung Chiang, Chien-Jui Huang, Hsui-Chi Tu, (Shang-Cheng Hung, Yan-Shen Shan*, Gwo-Bin Lee*, Exfoliated tumor cells in bile as a promising indicator of disease status in cholangiocarcinoma, SENSORS AND ACTUATORS B-CHEMICAL, vol. 346, 130526, 2021
2021 Gannedi V, Villuri BK, Reddy SN, Ku CC, Wong CH*, (Hung SC*, Practical Remdesivir Synthesis through One-Pot Organocatalyzed Asymmetric (S)-P-Phosphoramidation., The Journal of Organic Chemistry, vol. 86(7), 4977-4985, 2021
2021 Jan JT, Cheng TR, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, Cheng WC, Chein RJ, Mao SS, Liang PH, Ma C*, (Hung SC*, Wong CH*, Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection., Proceedings of the National Academy of Sciences of the United States of America, vol. 118(5), 2021
2021 Priya Gopinathan, Tsung-Han Lua, Nai-Jung Chiang, Chien-Jui Huang, Hsui-Chi Tu, (Shang-Cheng Hung, Yan-Shen Shan*, Gwo-Bin Lee*, Exfoliated tumor cells in bile as a promising indicator of disease status in cholangiocarcinoma, SENSORS AND ACTUATORS B-CHEMICAL, vol. 346, 130526, 2021
2020 Chiu LT, Sabbavarapu NM, Lin WC, Fan CY, Wu CC, Cheng TR, Wong CH*, (Hung SC*, Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1., Journal of the American Chemical Society, vol. 142(11), 5282-5292, 2020
2020 Yeh CJ, Zulueta MML, Li YK, (Hung SC*, Synthesis of hyaluronic acid oligosaccharides with a GlcNAc-GlcA repeating pattern and their binding affinity with CD44., Organic & biomolecular chemistry, vol. 18(28), 5370-5387, 2020
2020 Lin TS, Hsieh CH, Kuo C, Juang YP, Hsieh YSY, Chiang H, (Hung SC, Jiang CC, Liang PH, Sulfation pattern of chondroitin sulfate in human osteoarthritis cartilages reveals a lower level of chondroitin-4-sulfate., Carbohydrate polymers, vol. 229, 115496, 2020
2020 Gopinathan P, Chiang NJ, Bandaru A, Sinha A, Huang WY, (Hung SC*, Shan YS, Lee GB, Exploring Circulating Tumor Cells in Cholangiocarcinoma Using a Novel Glycosaminoglycan Probe on a Microfluidic Platform., Advanced healthcare materials, vol. 9(10), e1901875, 2020
2020 Farabi K, Manabe Y, Ichikawa H, Miyake S, Tsutsui M, Kabayama K, Yamaji T, Tanaka K, (Hung SC, Fukase K, Concise and Reliable Syntheses of Glycodendrimers via Self-Activating Click Chemistry: A Robust Strategy for Mimicking Multivalent Glycan-Pathogen Interactions., The Journal of organic chemistry, vol. 85(24), 16014-16023, 2020
2020 Gopinathan Priya, Chiang Nai-Jung, Wang Chih-Hung, Sinha Anirban, Tsai Yi-Cheng, Tu Hsiu-Chi, (Hung Shang-Cheng, Hsu Pang-Hung, Shan Yan-Shen, Lee Gwo-Bin, Aptamer probed isolation of circulating tumor cells in cholangiocarcinoma patients, SENSORS AND ACTUATORS B-CHEMICAL, vol. 322, 128569, 2020
2020 Chiu LT, Sabbavarapu NM, Lin WC, Fan CY, Wu CC, Cheng TR, Wong CH*, (Hung SC*, Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1., Journal of the American Chemical Society, vol. 142(11), 5282-5292, 2020
2020 Yeh CJ, Zulueta MML, Li YK, (Hung SC*, Synthesis of hyaluronic acid oligosaccharides with a GlcNAc-GlcA repeating pattern and their binding affinity with CD44., Organic & biomolecular chemistry, vol. 18(28), 5370-5387, 2020
2020 Lin TS, Hsieh CH, Kuo C, Juang YP, Hsieh YSY, Chiang H, (Hung SC, Jiang CC, Liang PH, Sulfation pattern of chondroitin sulfate in human osteoarthritis cartilages reveals a lower level of chondroitin-4-sulfate., Carbohydrate polymers, vol. 229, 115496, 2020
2020 Gopinathan P, Chiang NJ, Bandaru A, Sinha A, Huang WY, (Hung SC*, Shan YS, Lee GB, Exploring Circulating Tumor Cells in Cholangiocarcinoma Using a Novel Glycosaminoglycan Probe on a Microfluidic Platform., Advanced healthcare materials, vol. 9(10), e1901875, 2020
2020 Farabi K, Manabe Y, Ichikawa H, Miyake S, Tsutsui M, Kabayama K, Yamaji T, Tanaka K, (Hung SC, Fukase K, Concise and Reliable Syntheses of Glycodendrimers via Self-Activating Click Chemistry: A Robust Strategy for Mimicking Multivalent Glycan-Pathogen Interactions., The Journal of organic chemistry, vol. 85(24), 16014-16023, 2020
2020 Gopinathan Priya, Chiang Nai-Jung, Wang Chih-Hung, Sinha Anirban, Tsai Yi-Cheng, Tu Hsiu-Chi, (Hung Shang-Cheng, Hsu Pang-Hung, Shan Yan-Shen, Lee Gwo-Bin, Aptamer probed isolation of circulating tumor cells in cholangiocarcinoma patients, SENSORS AND ACTUATORS B-CHEMICAL, vol. 322, 128569, 2020
2019 Kameyama, H.; Uchimura, K.; Yamashita, T.; Kuwabara, K.; Mizuguchi, M.; (Hung, S.-C.); Okuhira, K.; Masuda, T.; Kosugi, T.; Ohgita, T.; Saito, H.; Ando Y.; Nishitsuji, K.*, The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity, Am. J. Pathol, vol. 189, 308-319, 2019
2019 Yeh, C.-J.; Ku, C.-C.; Lin, W.-C.; Fan, C.-Y.; Medel Manuel L. Zulueta, M. M. L.; Manabe, Y.; Fukase, K.; Li, Y.-K.; (Hung, S.-C.*, Single-Step Per-O-Sulfonation of Sugar Oligomers with Concomitant 1,6-Anhydro Bridge Formation for Binding Fibroblast Growth Factors, CHEMBIOCHEM, vol. 20, 237-240, 2019
2019 Lin, Y.-C.; Ko, Y.-C.; (Hung, S.-C.); Lee, J.-H.; Lin, Y.-T.; Tsai, J.-Y.; Kung, P.-H.; Tsai, M.-C.; Chen, Y.-F.; Wu, C.-C.*, Selective Inhibition of PAR4-mediated Platelet Activation by a Synthetic Nonanticoagulant, Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 39, 694-703, 2019
2019 Sakamoto K, Ozaki T, Ko YC, Tsai CF, Gong Y, Morozumi M, Ishikawa Y, Uchimura K, Nadanaka S, Kitagawa H, Zulueta MML, Bandaru A, Tamura JI, (Hung SC, Kadomatsu K, Glycan sulfation patterns define autophagy flux at axon tip via PTPRsigma-cortactin axis., Nature Chemical Biology, vol. 15(7), 699-709, 2019
2019 Sianturi J, Manabe Y, Li HS, Chiu LT, Chang TC, Tokunaga K, Kabayama K, Tanemura M, Takamatsu S, Miyoshi E, (Hung SC, Fukase K, Development of α-Gal-Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies., Angewandte Chemie (International ed. in English), vol. 58(14), 4526-4530, 2019
2019 Shen, K. M.; Sabbavarapu, N. M.; Fu, C.-Y.; Jan, J.-T.; Wang, J.-R.; (Hung, S.-C.*); Lee, G.-B.*, An Integrated Microfluidic System for Rapid Detection and Multiple Subtyping of Influenza A Viruses by Using Glycan-Coated Magnetic Beads and RT-PCR, Lab Chip, vol. 19, 1277-1286, 2019
2019 Kameyama, H.; Uchimura, K.; Yamashita, T.; Kuwabara, K.; Mizuguchi, M.; (Hung, S.-C.); Okuhira, K.; Masuda, T.; Kosugi, T.; Ohgita, T.; Saito, H.; Ando Y.; Nishitsuji, K.*, The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity, Am. J. Pathol, vol. 189, 308-319, 2019
2019 Yeh, C.-J.; Ku, C.-C.; Lin, W.-C.; Fan, C.-Y.; Medel Manuel L. Zulueta, M. M. L.; Manabe, Y.; Fukase, K.; Li, Y.-K.; (Hung, S.-C.*, Single-Step Per-O-Sulfonation of Sugar Oligomers with Concomitant 1,6-Anhydro Bridge Formation for Binding Fibroblast Growth Factors, CHEMBIOCHEM, vol. 20, 237-240, 2019
2019 Lin, Y.-C.; Ko, Y.-C.; (Hung, S.-C.); Lee, J.-H.; Lin, Y.-T.; Tsai, J.-Y.; Kung, P.-H.; Tsai, M.-C.; Chen, Y.-F.; Wu, C.-C.*, Selective Inhibition of PAR4-mediated Platelet Activation by a Synthetic Nonanticoagulant, Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 39, 694-703, 2019
2019 Sakamoto K, Ozaki T, Ko YC, Tsai CF, Gong Y, Morozumi M, Ishikawa Y, Uchimura K, Nadanaka S, Kitagawa H, Zulueta MML, Bandaru A, Tamura JI, (Hung SC, Kadomatsu K, Glycan sulfation patterns define autophagy flux at axon tip via PTPRsigma-cortactin axis., Nature Chemical Biology, vol. 15(7), 699-709, 2019
2019 Sianturi J, Manabe Y, Li HS, Chiu LT, Chang TC, Tokunaga K, Kabayama K, Tanemura M, Takamatsu S, Miyoshi E, (Hung SC, Fukase K, Development of α-Gal-Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies., Angewandte Chemie (International ed. in English), vol. 58(14), 4526-4530, 2019
2019 Shen, K. M.; Sabbavarapu, N. M.; Fu, C.-Y.; Jan, J.-T.; Wang, J.-R.; (Hung, S.-C.*); Lee, G.-B.*, An Integrated Microfluidic System for Rapid Detection and Multiple Subtyping of Influenza A Viruses by Using Glycan-Coated Magnetic Beads and RT-PCR, Lab Chip, vol. 19, 1277-1286, 2019
2018 Zulueta, M. M. L.*; Chyan, C.-L.; (Hung, S.-C.*, Structural Analysis of Synthetic Heparan Sulfate Oligosaccharides with Fibroblast Growth Factors and Heparin-Binding Hemagglutinin, Curr. Opin. Struct. Biol., vol. 50, 126-133, 2018
2018 Wang, C.-C.*; Sabbavarapu, N. M.; Podilapu, A. R.; Liao, P.-H.; (Hung, S.-C.*, One-Pot Protection, Glycosylation and Protection-Glycosylation Strategies of Carbohydrates, Chem. Rev., vol. 118, 8025-8104, 2018
2018 Zulueta, M. M. L.*; Chyan, C.-L.; (Hung, S.-C.*, Structural Analysis of Synthetic Heparan Sulfate Oligosaccharides with Fibroblast Growth Factors and Heparin-Binding Hemagglutinin, Curr. Opin. Struct. Biol., vol. 50, 126-133, 2018
2018 Wang, C.-C.*; Sabbavarapu, N. M.; Podilapu, A. R.; Liao, P.-H.; (Hung, S.-C.*, One-Pot Protection, Glycosylation and Protection-Glycosylation Strategies of Carbohydrates, Chem. Rev., vol. 118, 8025-8104, 2018
2017 Padiyar, L. T.; Zulueta, M. M. L.; Sabbavarapu, N. M.; (Hung, S.-C.*, Yb(OTf)3-Catalyzed Desymmetrization of myo-Inositol-1,3,5-Orthoformate and Its Application in the Synthesis of Chiral Inositol Phosphates, J. Org. Chem, vol. 82, 11418-11430, 2017
2017 Tsai, C.-T.; Zulueta, M. M. L.; (Hung, S.-C.*, Synthetic Heparin and Heparan Sulfate: Probes in Defining Biological Functions, Curr. Opin. Chem. Biol., vol. 21, 152-159, 2017
2017 Huang, T.-Y.; Irene, D.; Ku, C.-C.; Zulueta, M. M. L.; Tai, T.-J.; Lain, S.-H.; Cheng, C.-P.; Tsai, P.-X.; Lin, S.-Y.; Chen, Z.-G.; Hsiao, C.-D.; Chyan, C.-L.*; (Hung, S.-C.*, Structure of the Complex between a Heparan Sulfate Octasaccharide and Mycobacterial Heparin-Binding Hemagglutinin, Angew. Chem. Int. Ed, vol. 56, 4192-4196, 2017
2017 Ho, K.-M.; Zulueta, M. M. L.; (Hung, S.-C.*, Stereoselective One-pot Synthesis of Polypropionates, Nat. Commun, vol. 8, 679, 2017
2017 Hughes, A. J.; Meneghetti, M. C. Z.; Huang, T.-Y.; (Hung, S.-C.); Elli, S.; Guerrini, M.; Rudd, T. R.; Lima, M. A.*; Yates, E. A.*, Investigating the Relationship between Temperature, Conformation and Calcium Binding in Heparin Model Oligosaccharides, Carbohydr. Res, vol. 438, 58-64, 2017
2017 Zheng RB, Jegouzo SAF, Joe M, Bai Y, Tran HA, Shen K, Saupe J, Xia L, Ahmed MF, Liu YH, Patil PS, Tripathi A, (Hung SC, Taylor ME, Lowary TL, Drickamer K, Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans., ACS chemical biology, vol. 12(12), 2990-3002, 2017
2017 Prados-Rosales, R.*; Carreño L.; Weinrick, B.; Lowary, T.; Baena, A.; Joe, M.; Bai, Y.; Kalscheuer, R.; Batista-Gonzalez, A.; Saavedra, N.; Chen, T.; Blanc, C.; (Hung, S.-C.); Tripathi, A.; Xu, J.; Glatman-Freedman, A.; Jacobs, W.; Chan, J.; Porcelli, S.; Achkar, J.; Casadevall, A., Enhanced Control of Mycobacterium tuberculosis Extrapulmonary Dissemination in Mice by an Arabinomannan-Protein Conjugate Vaccine, PLOS PATHOGENS, vol. 13, e1006250, 2017
2017 Padiyar, L. T.; Zulueta, M. M. L.; Sabbavarapu, N. M.; (Hung, S.-C.*, Yb(OTf)3-Catalyzed Desymmetrization of myo-Inositol-1,3,5-Orthoformate and Its Application in the Synthesis of Chiral Inositol Phosphates, J. Org. Chem, vol. 82, 11418-11430, 2017
2017 Tsai, C.-T.; Zulueta, M. M. L.; (Hung, S.-C.*, Synthetic Heparin and Heparan Sulfate: Probes in Defining Biological Functions, Curr. Opin. Chem. Biol., vol. 21, 152-159, 2017
2017 Huang, T.-Y.; Irene, D.; Ku, C.-C.; Zulueta, M. M. L.; Tai, T.-J.; Lain, S.-H.; Cheng, C.-P.; Tsai, P.-X.; Lin, S.-Y.; Chen, Z.-G.; Hsiao, C.-D.; Chyan, C.-L.*; (Hung, S.-C.*, Structure of the Complex between a Heparan Sulfate Octasaccharide and Mycobacterial Heparin-Binding Hemagglutinin, Angew. Chem. Int. Ed, vol. 56, 4192-4196, 2017
2017 Ho, K.-M.; Zulueta, M. M. L.; (Hung, S.-C.*, Stereoselective One-pot Synthesis of Polypropionates, Nat. Commun, vol. 8, 679, 2017
2017 Hughes, A. J.; Meneghetti, M. C. Z.; Huang, T.-Y.; (Hung, S.-C.); Elli, S.; Guerrini, M.; Rudd, T. R.; Lima, M. A.*; Yates, E. A.*, Investigating the Relationship between Temperature, Conformation and Calcium Binding in Heparin Model Oligosaccharides, Carbohydr. Res, vol. 438, 58-64, 2017
2017 Zheng RB, Jegouzo SAF, Joe M, Bai Y, Tran HA, Shen K, Saupe J, Xia L, Ahmed MF, Liu YH, Patil PS, Tripathi A, (Hung SC, Taylor ME, Lowary TL, Drickamer K, Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans., ACS chemical biology, vol. 12(12), 2990-3002, 2017
2017 Prados-Rosales, R.*; Carreño L.; Weinrick, B.; Lowary, T.; Baena, A.; Joe, M.; Bai, Y.; Kalscheuer, R.; Batista-Gonzalez, A.; Saavedra, N.; Chen, T.; Blanc, C.; (Hung, S.-C.); Tripathi, A.; Xu, J.; Glatman-Freedman, A.; Jacobs, W.; Chan, J.; Porcelli, S.; Achkar, J.; Casadevall, A., Enhanced Control of Mycobacterium tuberculosis Extrapulmonary Dissemination in Mice by an Arabinomannan-Protein Conjugate Vaccine, PLOS PATHOGENS, vol. 13, e1006250, 2017
2016 Ho, G.-M.; Huang, C.-J., Li, E. Y.-T.*, Hsu, S.-K.; Wu, T.; Zulueta, M. M. L.; Wu, K. P.-C.; (Hung, S.-C.*, Unconventional exo-Selectivity in Thermal Normal-Electron-Demand Diels–Alder Reactions, Sci. Rep, vol. 6, 35147, 2016
2016 Liang, W. G.; Huang, T.-Y.; Zulueta, M. M. L.; (Hung, S.-C.*); Tang, W.-J.*, Structural Basis for Oligomerization and Glycosaminoglycan-Binding of CCL5 and CCL3, Proc. Natl. Acad. Sci. USA, vol. 113, 5000-5005, 2016
2016 Stewart, K. L.; Hughes, E.; Yates, E. A.; Huang, T.-Y.; Lima, M. A.; Rudd, T. R.; Guerrini, M.; (Hung, S.-C.*); Radford, S. E.*; Middleton, D. A.*, Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils, J. Am. Chem. Soc., vol. 138, 8328-8331, 2016
2016 Ho, G.-M.; Huang, C.-J., Li, E. Y.-T.*, Hsu, S.-K.; Wu, T.; Zulueta, M. M. L.; Wu, K. P.-C.; (Hung, S.-C.*, Unconventional exo-Selectivity in Thermal Normal-Electron-Demand Diels–Alder Reactions, Sci. Rep, vol. 6, 35147, 2016
2016 Liang, W. G.; Huang, T.-Y.; Zulueta, M. M. L.; (Hung, S.-C.*); Tang, W.-J.*, Structural Basis for Oligomerization and Glycosaminoglycan-Binding of CCL5 and CCL3, Proc. Natl. Acad. Sci. USA, vol. 113, 5000-5005, 2016
2016 Stewart, K. L.; Hughes, E.; Yates, E. A.; Huang, T.-Y.; Lima, M. A.; Rudd, T. R.; Guerrini, M.; (Hung, S.-C.*); Radford, S. E.*; Middleton, D. A.*, Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils, J. Am. Chem. Soc., vol. 138, 8328-8331, 2016
2015 Patil PS; Cheng TJR; Zulueta MM; Yang ST; Lico LS; (Hung SC.*, Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity., Nat Commun., vol. 6, 7239, 2015
2015 Medel Manuel L. Zulueta*, Donala Janreddy, Shang-Cheng Hung*, One-Pot Methods for the Protection and Assembly of Sugars, ISRAEL JOURNAL OF CHEMISTRY, vol. 55(3), 347-359, 2015
2015 Kuwabara K; Nishitsuji K; Uchimura K; (Hung SC); Mizuguchi M; Nakajima H; Mikawa S; Kobayashi N; Saito H; Sakashita N., Cellular interaction and cytotoxicity of the Iowa mutation of apolipoprotein A-I (ApoA-IIowa) amyloid mediated by sulfate moieties of heparan sulfate., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, 24210-24221, 2015
2015 Patil PS; Cheng TJR; Zulueta MM; Yang ST; Lico LS; (Hung SC.*, Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity., Nat Commun., vol. 6, 7239, 2015
2015 Medel Manuel L. Zulueta*, Donala Janreddy, Shang-Cheng Hung*, One-Pot Methods for the Protection and Assembly of Sugars, ISRAEL JOURNAL OF CHEMISTRY, vol. 55(3), 347-359, 2015
2015 Kuwabara K; Nishitsuji K; Uchimura K; (Hung SC); Mizuguchi M; Nakajima H; Mikawa S; Kobayashi N; Saito H; Sakashita N., Cellular interaction and cytotoxicity of the Iowa mutation of apolipoprotein A-I (ApoA-IIowa) amyloid mediated by sulfate moieties of heparan sulfate., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 290, 24210-24221, 2015
2014 Huang, T.-Y.; Zulueta, M. M. L.; (Hung, S.-C., Regioselective One-pot Protection, Protection-Glycosylation and Protection- Glycosylation-Glycosylation of Carbohydrates: A Case Study with D-Glucose, Organic & Biomolecular Chemistry, vol. 12(2), 376-382, 2014
2014 Patil, P. S.; Zulueta, M. M. L.; (Hung, S.-C., Synthesis of Phosphatidylinositol Mannosides, Journal of the Chinese Chemical Society, vol. 61, 151-162, 2014
2014 Hsu Y; Ma HH; Lico LS; Jan JT; Fukase K; Uchinashi Y; Zulueta MM; (Hung SC.*, One-pot synthesis of N-acetyl- and N-glycolylneuraminic acid capped trisaccharides and evaluation of their influenza A(H1N1) inhibition., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 53, 2413-2416, 2014
2014 Li YC; Ho IH; Ku CC; Zhong YQ; Hu YP; Chen ZG; Chen CY; Lin WC; Zulueta MM; (Hung SC*); Lin MG; Wang CC; (Hsiao CD*, Interactions That Influence the Binding of Synthetic Heparan Sulfate Based Disaccharides to Fibroblast Growth Factor-2, ACS Chem Biol., vol. 9, 1912-1717, 2014
2014 Chang CH; Lico LS; Huang TY; Lin SY; Chang CL; Arco SD; (Hung SC.*, Synthesis of the heparin-based anticoagulant drug Fondaparinux., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 53, 9876-9879, 2014
2014 Ko YC; Tsai CF; Wang CC*; Dhurandhare VM; Hu PL; Su TY; Lico LS; Zulueta MM; (Hung SC*, Microwave-assisted one-pot synthesis of 1,6-anhydrosugars and orthogonally protected thioglycosides., J Am Chem Soc., vol. 136, 14425-14431, 2014
2014 Huang, T.-Y.; Zulueta, M. M. L.; (Hung, S.-C., Regioselective One-pot Protection, Protection-Glycosylation and Protection- Glycosylation-Glycosylation of Carbohydrates: A Case Study with D-Glucose, Organic & Biomolecular Chemistry, vol. 12(2), 376-382, 2014
2014 Patil, P. S.; Zulueta, M. M. L.; (Hung, S.-C., Synthesis of Phosphatidylinositol Mannosides, Journal of the Chinese Chemical Society, vol. 61, 151-162, 2014
2014 Hsu Y; Ma HH; Lico LS; Jan JT; Fukase K; Uchinashi Y; Zulueta MM; (Hung SC.*, One-pot synthesis of N-acetyl- and N-glycolylneuraminic acid capped trisaccharides and evaluation of their influenza A(H1N1) inhibition., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 53, 2413-2416, 2014
2014 Li YC; Ho IH; Ku CC; Zhong YQ; Hu YP; Chen ZG; Chen CY; Lin WC; Zulueta MM; (Hung SC*); Lin MG; Wang CC; (Hsiao CD*, Interactions That Influence the Binding of Synthetic Heparan Sulfate Based Disaccharides to Fibroblast Growth Factor-2, ACS Chem Biol., vol. 9, 1912-1717, 2014
2014 Chang CH; Lico LS; Huang TY; Lin SY; Chang CL; Arco SD; (Hung SC.*, Synthesis of the heparin-based anticoagulant drug Fondaparinux., ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 53, 9876-9879, 2014
2014 Ko YC; Tsai CF; Wang CC*; Dhurandhare VM; Hu PL; Su TY; Lico LS; Zulueta MM; (Hung SC*, Microwave-assisted one-pot synthesis of 1,6-anhydrosugars and orthogonally protected thioglycosides., J Am Chem Soc., vol. 136, 14425-14431, 2014
2013 Zulueta, M. M. L.; Lin, S.-Y.; Hu, Y.-P.; Hung, S.-C., Synthetic Heparin and Heparan Sulfate Oligosaccharides and their Protein Interactions, Current Opinion in Chemical Biology, vol. 17(6), 1023-1029, 2013
2013 Woolfson, D. N.; Hung, S.-C., Synthetic Biomolecules, Current Opinion in Chemical Biology, vol. 17(6), 925-928, 2013
2013 Zulueta, M. M. L.; Zhong, Y.-Q.; Hung, S.-C., Synthesis of Rare L-Hexoses and Their Related Biomolecules, Chemical Communications, vol. 49(32), 3275-3287, 2013
2013 Lu, F.-C.; Lico, L. S.; Hung, S.-C., Synthesis of Fluorogenic Substrate for α-L-Iduronidase, ARKIVOC, vol. 2013(2), 13-21, 2013
2013 Patil, P. S.; Lee, C.-C.; Huang, Y.-W.; Zulueta, M. M. L.; Hung, S.-C., Regioselective and Stereoselective Benzylidene Installation and One-pot Protection of D-mannose, Organic & Biomolecular Chemistry, vol. 11(16), 2605-2612, 2013
2013 Zulueta, M. M. L.; Lin, S.-Y.; Hung, S.-C., Chemical Synthesis of Oligosaccharides Based on Heparin and Heparan Sulfate, Trends in Glycoscience and Glycotechnology, vol. 25, 141-158, 2013
2013 Zulueta, M. M. L.; Lin, S.-Y.; Hu, Y.-P.; Hung, S.-C., Synthetic Heparin and Heparan Sulfate Oligosaccharides and their Protein Interactions, Current Opinion in Chemical Biology, vol. 17(6), 1023-1029, 2013
2013 Woolfson, D. N.; Hung, S.-C., Synthetic Biomolecules, Current Opinion in Chemical Biology, vol. 17(6), 925-928, 2013
2013 Zulueta, M. M. L.; Zhong, Y.-Q.; Hung, S.-C., Synthesis of Rare L-Hexoses and Their Related Biomolecules, Chemical Communications, vol. 49(32), 3275-3287, 2013
2013 Lu, F.-C.; Lico, L. S.; Hung, S.-C., Synthesis of Fluorogenic Substrate for α-L-Iduronidase, ARKIVOC, vol. 2013(2), 13-21, 2013
2013 Patil, P. S.; Lee, C.-C.; Huang, Y.-W.; Zulueta, M. M. L.; Hung, S.-C., Regioselective and Stereoselective Benzylidene Installation and One-pot Protection of D-mannose, Organic & Biomolecular Chemistry, vol. 11(16), 2605-2612, 2013
2013 Zulueta, M. M. L.; Lin, S.-Y.; Hung, S.-C., Chemical Synthesis of Oligosaccharides Based on Heparin and Heparan Sulfate, Trends in Glycoscience and Glycotechnology, vol. 25, 141-158, 2013
2012 Hung, S.-C.; Lu, X.-A.; Lee, J.-C.; Fang, S.-L.; Fan, T.-C.; Chang, M. D.-T.; Zulueta, M. M. L.; Chiu, L.-T., Synthesis of Heparin Oligosaccharides and Their Interaction with Eosinophil-Derived Neurotoxin, Org. Biomol. Chem., vol. 10, 760-772, 2012
2012 Hsu, C.-Y.; Lee, I-C.; Lico, L. S.; Uang, B.-J.; Hung, S.-C., Synthesis of a Furanosyl-pyranone Derivative Related to the Tri-O-heterocyclic Core of Herbicidins, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 59, 421-425, 2012
2012 Luo, S.-Y.; Tripathi, A.; Zulueta, M. M. L.; Hung, S.-C., 2-Allylphenyl Glycosides as Glycosyl Donors for Sugar Coupling, Carbohydrate Research, vol. 352, 197-201, 2012
2012 Hsu, Y.; Lu, X.-A.; Zulueta, M. M. L.; Tsai, C.-M.; Lin, K.-I; Hung, S.-C.; Wong, C.-H., Acyl and Silyl Group Effects in Reactivity-based One-pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4, J. Am. Chem. Soc., vol. 134, 4549-4552, 2012
2012 Zulueta, M. M. L.; Lin, S.-Y.; Lin, Y.-T.; Huang, C.-J.; Wang, C.-C.; Ku, C.-C.; Shi, Z.; Chyan, C.-L.; Irene, D.; Lim, L.-H.; Tsai, T.-I; Hu, Y.-P.; Liu, J.-Y.; Chang, W.; Arco, S. D.; Wong, C.-H.; Hung, S.-C., α-Glycosylation by D-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogs that Interact with Mycobacterial Heparin-Binding Hemagglutinin, J. Am. Chem. Soc., vol. 134(21), 8988-8995, 2012
2012 Hu, Y.-P.; Zhong, Y.-Q.; Chen, Z.-G.; Chen, C.-Y.; Shi, Z.; Zulueta, M. M. L.; Ku, C.-C.; Lee, P.-Y.; Wang, C.-C.; Hung, S.-C., Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor-1 Interaction, J. Am. Chem. Soc., vol. 134(51), 20722-20727, 2012
2012 Hung, S.-C.; Lu, X.-A.; Lee, J.-C.; Fang, S.-L.; Fan, T.-C.; Chang, M. D.-T.; Zulueta, M. M. L.; Chiu, L.-T., Synthesis of Heparin Oligosaccharides and Their Interaction with Eosinophil-Derived Neurotoxin, Org. Biomol. Chem., vol. 10, 760-772, 2012
2012 Hsu, C.-Y.; Lee, I-C.; Lico, L. S.; Uang, B.-J.; Hung, S.-C., Synthesis of a Furanosyl-pyranone Derivative Related to the Tri-O-heterocyclic Core of Herbicidins, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol. 59, 421-425, 2012
2012 Luo, S.-Y.; Tripathi, A.; Zulueta, M. M. L.; Hung, S.-C., 2-Allylphenyl Glycosides as Glycosyl Donors for Sugar Coupling, Carbohydrate Research, vol. 352, 197-201, 2012
2012 Hsu, Y.; Lu, X.-A.; Zulueta, M. M. L.; Tsai, C.-M.; Lin, K.-I; Hung, S.-C.; Wong, C.-H., Acyl and Silyl Group Effects in Reactivity-based One-pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4, J. Am. Chem. Soc., vol. 134, 4549-4552, 2012
2012 Zulueta, M. M. L.; Lin, S.-Y.; Lin, Y.-T.; Huang, C.-J.; Wang, C.-C.; Ku, C.-C.; Shi, Z.; Chyan, C.-L.; Irene, D.; Lim, L.-H.; Tsai, T.-I; Hu, Y.-P.; Liu, J.-Y.; Chang, W.; Arco, S. D.; Wong, C.-H.; Hung, S.-C., α-Glycosylation by D-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogs that Interact with Mycobacterial Heparin-Binding Hemagglutinin, J. Am. Chem. Soc., vol. 134(21), 8988-8995, 2012
2012 Hu, Y.-P.; Zhong, Y.-Q.; Chen, Z.-G.; Chen, C.-Y.; Shi, Z.; Zulueta, M. M. L.; Ku, C.-C.; Lee, P.-Y.; Wang, C.-C.; Hung, S.-C., Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor-1 Interaction, J. Am. Chem. Soc., vol. 134(51), 20722-20727, 2012
2011 Wang, C.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C., Synthesis of Hemagglutinin-Binding Trisaccharides, Advances in Experimental Medicine and Biology, vol. 705, 691-726, 2011
2011 Hu, Y.-P.; Lin, S.-Y.; Huang, C.-Y.; Zulueta, M. M. L.; Liu, J.-Y.; Chang, W.; Hung, S.-C., Synthesis of 3-O-Sulfonated Cell-Surface Heparan Sulfate Octasaccharides that Inhibit Herpes Simplex Virus Type 1 Host-Cell Interaction, Nature Chemistry, vol. 3, 557–563, 2011
2011 Wang, C.-C.; Zulueta, M. M. L.; Hung, S.-C., Regioselective One-pot Protection and Protection-glycosylation of Carbohydrates, Chimia, vol. 65, 54-58, 2011
2011 Huang, T.-Y.; Zulueta, M. M. L.; Hung, S.-C., One-Pot Strategies for the Synthesis of the Tetrasaccharide Linkage Region of Proteoglycans, Org. Lett., vol. 13, 1506–1509, 2011
2011 Lee, I.-C.; Zulueta, M. M. L.; Shie, C.-R.; Arco, S. D.; Hung, S.-C., Deuterium-Isotope Study on the Regioselective Ring Opening of Benzylidene Acetals, Org. Biomol. Chem., vol. 9, 7655–7658, 2011
2011 Chung, C.-C.; Zulueta, M. M. L.; Padiyar, L. T.; Hung, S.-C., Desymmetrization of 2,4,5,6-Tetra-O-benzyl-D-myo-inositol for the Synthesis of Mycothiol, Org. Lett., vol. 13, 5496–5499, 2011
2011 Hsu, C.-H.; Hung, S.-C.; Wu, C.-Y.; Wong, C.-H., Toward Automatic Oligosaccharide Synthesis, Angewandte Chemie-International Edition, vol. 50(50), 11872-11923, 2011
2011 Wang, C.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C., Synthesis of Hemagglutinin-Binding Trisaccharides, Advances in Experimental Medicine and Biology, vol. 705, 691-726, 2011
2011 Hu, Y.-P.; Lin, S.-Y.; Huang, C.-Y.; Zulueta, M. M. L.; Liu, J.-Y.; Chang, W.; Hung, S.-C., Synthesis of 3-O-Sulfonated Cell-Surface Heparan Sulfate Octasaccharides that Inhibit Herpes Simplex Virus Type 1 Host-Cell Interaction, Nature Chemistry, vol. 3, 557–563, 2011
2011 Wang, C.-C.; Zulueta, M. M. L.; Hung, S.-C., Regioselective One-pot Protection and Protection-glycosylation of Carbohydrates, Chimia, vol. 65, 54-58, 2011
2011 Huang, T.-Y.; Zulueta, M. M. L.; Hung, S.-C., One-Pot Strategies for the Synthesis of the Tetrasaccharide Linkage Region of Proteoglycans, Org. Lett., vol. 13, 1506–1509, 2011
2011 Lee, I.-C.; Zulueta, M. M. L.; Shie, C.-R.; Arco, S. D.; Hung, S.-C., Deuterium-Isotope Study on the Regioselective Ring Opening of Benzylidene Acetals, Org. Biomol. Chem., vol. 9, 7655–7658, 2011
2011 Chung, C.-C.; Zulueta, M. M. L.; Padiyar, L. T.; Hung, S.-C., Desymmetrization of 2,4,5,6-Tetra-O-benzyl-D-myo-inositol for the Synthesis of Mycothiol, Org. Lett., vol. 13, 5496–5499, 2011
2011 Hsu, C.-H.; Hung, S.-C.; Wu, C.-Y.; Wong, C.-H., Toward Automatic Oligosaccharide Synthesis, Angewandte Chemie-International Edition, vol. 50(50), 11872-11923, 2011
2010 Hung, S.-C., Synthesis of Mycobacterial Cell Envelope Components, Natural Sciences Newsletter, vol. 22, 43-46, 2010
2010 Padiyar, L. T.; Wen, Y.-S.; Hung, S.-C., Metal Trifluromethanesulfonate-Catalyzed Regioselective Acylation of myo-Inositol Orthoformate, Chem. Commun., vol. 46, 5524-5526, 2010
2010 Patil, P. S.; Hung, S.-C., Synthesis of Mycobacterial Triacylated Phosphatidylinositol Dimannoside Containing an Acyl Lipid Chain at 3-O of Inositol, Org. Lett., vol. 12, 2618-2621, 2010
2010 Chang, K.-L.; Zulueta, M. M. L.; Lu, X.-A.; Zhong, Y.-Q.; Hung, S.-C., Regioselective One-pot Protection of D-Glucosamine, J. Org. Chem, vol. 75, 7424-7427, 2010
2010 Hung, S.-C., Synthesis of Mycobacterial Cell Envelope Components, Natural Sciences Newsletter, vol. 22, 43-46, 2010
2010 Padiyar, L. T.; Wen, Y.-S.; Hung, S.-C., Metal Trifluromethanesulfonate-Catalyzed Regioselective Acylation of myo-Inositol Orthoformate, Chem. Commun., vol. 46, 5524-5526, 2010
2010 Patil, P. S.; Hung, S.-C., Synthesis of Mycobacterial Triacylated Phosphatidylinositol Dimannoside Containing an Acyl Lipid Chain at 3-O of Inositol, Org. Lett., vol. 12, 2618-2621, 2010
2010 Chang, K.-L.; Zulueta, M. M. L.; Lu, X.-A.; Zhong, Y.-Q.; Hung, S.-C., Regioselective One-pot Protection of D-Glucosamine, J. Org. Chem, vol. 75, 7424-7427, 2010
2009 Patil, P. S.; Hung, S.-C., Total Synthesis of Phosphatidylinositol Dimmanoside: A Cell-Envelope Component of Mycobacterium tuberculosis, Chemistry-A European Journal, vol. 15, 1091–1094, 2009
2009 Chi, F.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C., Synthesis of Alginate Oligosaccharides Containing L-Guluronic Acids, Chemistry-An Asian Journal, vol. 4, 386–390, 2009
2009 Shie, C.-R.; Tzeng, Z.-H.; Wang, C.-C.; Hung, S.-C., Metal Trifluoromethanesulfonate-Catalyzed Regioselective Reductive Ring Opening of Benzylidene Acetals, Journal of the Chinese Chemical Society, vol. 56, 510–523, 2009
2009 Patil, P. S.; Hung, S.-C., Total Synthesis of Phosphatidylinositol Dimmanoside: A Cell-Envelope Component of Mycobacterium tuberculosis, Chemistry-A European Journal, vol. 15, 1091–1094, 2009
2009 Chi, F.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C., Synthesis of Alginate Oligosaccharides Containing L-Guluronic Acids, Chemistry-An Asian Journal, vol. 4, 386–390, 2009
2009 Shie, C.-R.; Tzeng, Z.-H.; Wang, C.-C.; Hung, S.-C., Metal Trifluoromethanesulfonate-Catalyzed Regioselective Reductive Ring Opening of Benzylidene Acetals, Journal of the Chinese Chemical Society, vol. 56, 510–523, 2009
2008 Wang, C.-C.; Kulkarni, S. S.; Lee, J.-C.; Luo, S.-Y.; Hung, S.-C., Regioselective One-pot Protection of Glucose, Nat. Protoc, vol. 3, 97–113, 2008
2008 Fan, T.-C.; Fang, S.-L.; Hwang, C.-S.; Hsu, C.-Y.; Lu, X.-A.; Hung, S.-C.; Lin, S.-C.; Chang, M. D.-T., Characterization of Molecular Interactions between Eosinophil Cationic Protein and Heparin, J. Biol. Chem., vol. 283, 25468–25474, 2008
2008 Luo, S.-Y.; Jang, Y.-J.; Liu, J.-Y.; Chu, C.-S.; Liao, C.-C.; Hung, S.-C., Carbohydrates-Templated Asymmetric Diels-Alder Reactions of Masked ortho-Benzoquinones for the Synthesis of Chiral Bicyclo[2.2.2]oct-5-en-2-ones, Angewandte Chemie-International Edition, vol. 47, 8082–8085, 2008
2008 Wang, C.-C.; Kulkarni, S. S.; Lee, J.-C.; Luo, S.-Y.; Hung, S.-C., Regioselective One-pot Protection of Glucose, Nat. Protoc, vol. 3, 97–113, 2008
2008 Fan, T.-C.; Fang, S.-L.; Hwang, C.-S.; Hsu, C.-Y.; Lu, X.-A.; Hung, S.-C.; Lin, S.-C.; Chang, M. D.-T., Characterization of Molecular Interactions between Eosinophil Cationic Protein and Heparin, J. Biol. Chem., vol. 283, 25468–25474, 2008
2008 Luo, S.-Y.; Jang, Y.-J.; Liu, J.-Y.; Chu, C.-S.; Liao, C.-C.; Hung, S.-C., Carbohydrates-Templated Asymmetric Diels-Alder Reactions of Masked ortho-Benzoquinones for the Synthesis of Chiral Bicyclo[2.2.2]oct-5-en-2-ones, Angewandte Chemie-International Edition, vol. 47, 8082–8085, 2008
2007 Wang, C.-C.; Kulkarni, S. S.; Hung, S.-C., Regioselective One-pot Protection of Carbohydrates, Synform, vol. 3, A32–A34, 2007
2007 Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Kulkarni, S. S.; Huang, Y.-W.; Lee, C.-C.; Chang, K.-L.; Hung, S.-C., Regioselective One-pot Protection of Carbohydrates, Nature, vol. 446, 896–899, 2007
2007 Wang, C.-C.; Kulkarni, S. S.; Hung, S.-C., Regioselective One-pot Protection of Carbohydrates, Synform, vol. 3, A32–A34, 2007
2007 Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Kulkarni, S. S.; Huang, Y.-W.; Lee, C.-C.; Chang, K.-L.; Hung, S.-C., Regioselective One-pot Protection of Carbohydrates, Nature, vol. 446, 896–899, 2007
2006 Lu, L.-D.; Shie, C.-R.; Kulkarni, S. S.; Pan, G.-R.; Lu, X.-A.; Hung, S.-C., Synthesis of 48 Disaccharide Building Blocks for the Assembly of a Heparin and Heparan Sulfate Oligosaccharide Library, Org. Lett, vol. 8, 5995–5998, 2006
2006 Luo, S.-Y.; Kulkarni, S. S.; Chou, C.-H.; Liao, W.-M.; Hung, S.-C., A Concise Synthesis of Tetrahydroxy-LCB, -Galactosyl Ceramide, and 1,4-Dideoxy-1,4-imino-L-ribitol via D-Allosamines as Key Building Blocks, J. Org. Chem., vol. 71, 1226–1229, 2006
2006 Lee, J.-C.; Pan, G.-R.; Kulkarni, S. S.; Luo, S.-Y.; Liao, C.-C.; Hung, S.-C., 2-Allyloxyphenyl Glycoside as a New and Stable Type of Glycosyl Donors, Tetrahedron Lett., vol. 47, 1621–1624, 2006
2006 Lu, L.-D.; Shie, C.-R.; Kulkarni, S. S.; Pan, G.-R.; Lu, X.-A.; Hung, S.-C., Synthesis of 48 Disaccharide Building Blocks for the Assembly of a Heparin and Heparan Sulfate Oligosaccharide Library, Org. Lett, vol. 8, 5995–5998, 2006
2006 Luo, S.-Y.; Kulkarni, S. S.; Chou, C.-H.; Liao, W.-M.; Hung, S.-C., A Concise Synthesis of Tetrahydroxy-LCB, -Galactosyl Ceramide, and 1,4-Dideoxy-1,4-imino-L-ribitol via D-Allosamines as Key Building Blocks, J. Org. Chem., vol. 71, 1226–1229, 2006
2006 Lee, J.-C.; Pan, G.-R.; Kulkarni, S. S.; Luo, S.-Y.; Liao, C.-C.; Hung, S.-C., 2-Allyloxyphenyl Glycoside as a New and Stable Type of Glycosyl Donors, Tetrahedron Lett., vol. 47, 1621–1624, 2006
2005 Kulkarni, S. S.; Liu, Y.-H.; Hung, S.-C., Neighboring Group Participation of 9-Anthracenylmethyl Group in Glycosylation: Preparation of Unusual C-Glycosides, J. Org. Chem., vol. 70, 2808–2811, 2005
2005 Kulkarni, S. S.; Hung, S.-C., Metal Trifluoromethanesulfonates as Versatile Catalysts in Carbohydrate Synthesis, Lett. Org. Chem., vol. 2, 670–677, 2005
2005 Shie, C.-R.; Tzeng, Z.-H.; Kulkarni, S. S.; Uang, B.-J.; Hsu, C.-Y.; Hung, S.-C., Cu(OTf)2 as an Efficient and Dual-Purpose Catalyst in the Regioselective Reductive Ring Opening of Benzylidene Acetals, Angewandte Chemie-International Edition, vol. 44, 1665–1668, 2005
2005 Chen, Y.-Y.; Luo, S.-Y.; Hung, S.-C.; Chan, S. I.; Tzou, D.-L. M., C-13 solid-state NMR chemical shift anisotropy analysis of the anomeric carbon in carbohydrates , Carbohydrate Research, vol. 340, 723-729, 2005
2005 Kulkarni, S. S.; Liu, Y.-H.; Hung, S.-C., Neighboring Group Participation of 9-Anthracenylmethyl Group in Glycosylation: Preparation of Unusual C-Glycosides, J. Org. Chem., vol. 70, 2808–2811, 2005
2005 Kulkarni, S. S.; Hung, S.-C., Metal Trifluoromethanesulfonates as Versatile Catalysts in Carbohydrate Synthesis, Lett. Org. Chem., vol. 2, 670–677, 2005
2005 Shie, C.-R.; Tzeng, Z.-H.; Kulkarni, S. S.; Uang, B.-J.; Hsu, C.-Y.; Hung, S.-C., Cu(OTf)2 as an Efficient and Dual-Purpose Catalyst in the Regioselective Reductive Ring Opening of Benzylidene Acetals, Angewandte Chemie-International Edition, vol. 44, 1665–1668, 2005
2005 Chen, Y.-Y.; Luo, S.-Y.; Hung, S.-C.; Chan, S. I.; Tzou, D.-L. M., C-13 solid-state NMR chemical shift anisotropy analysis of the anomeric carbon in carbohydrates , Carbohydrate Research, vol. 340, 723-729, 2005
2004 Lee, C.-J.; Lu, X.-A.; Kulkarni, S. S.; Wen, Y.-S.; Hung, S.-C., Synthesis of Heparin Oligosaccharides, J. Am. Chem. Soc., vol. 126, 476–477, 2004
2004 Chou, C. H., Wu, C. S., Chen, C. H., Lu, L. D., Kulkarni, S. S., Wong, C. H., Hung, S. C., Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues., Org Lett, vol. 6(4), 585-588, 2004
2004 Kulkarni, S. S.; Lee, J.-C.; Hung, S.-C., Recent Advances in the Applications of D- and L-1,6-Anhydropyranoses for the Synthesis of Oligosaccharides and Natural Products, Curr. Org. Chem., vol. 8, 475–509, 2004
2004 Lee, J.-C.; Chang, S.-W.; Liao, C.-C.; Chi, F.-C.; Chen, C.-S.; Wen, Y.-S.; Wang, C.-C.; Kulkarni, S. S.; Puranik, R.; Liu, Y.-H.; Hung, S.-C., From D-Glucose to Biologically Potent L-Hexoses: Synthesis of -L-Iduronidase Fluorogenic Detector and the Disaccharide Moieties of Bleomycin A2 and Heparan Sulfate, Chemistry-A European Journal, vol. 10, 399–415, 2004
2004 Kulkarni, S. S.; Chi, F.-C.; Hung, S.-C., Biologically Potent L-Hexoses and 6-Deoxy-L-hexoses: Their Syntheses and Applications, Journal of the Chinese Chemical Society, vol. 51, 1193–1200, 2004
2004 Lee, C.-J.; Lu, X.-A.; Kulkarni, S. S.; Wen, Y.-S.; Hung, S.-C., Synthesis of Heparin Oligosaccharides, J. Am. Chem. Soc., vol. 126, 476–477, 2004
2004 Chou, C. H., Wu, C. S., Chen, C. H., Lu, L. D., Kulkarni, S. S., Wong, C. H., Hung, S. C., Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues., Org Lett, vol. 6(4), 585-588, 2004
2004 Kulkarni, S. S.; Lee, J.-C.; Hung, S.-C., Recent Advances in the Applications of D- and L-1,6-Anhydropyranoses for the Synthesis of Oligosaccharides and Natural Products, Curr. Org. Chem., vol. 8, 475–509, 2004
2004 Lee, J.-C.; Chang, S.-W.; Liao, C.-C.; Chi, F.-C.; Chen, C.-S.; Wen, Y.-S.; Wang, C.-C.; Kulkarni, S. S.; Puranik, R.; Liu, Y.-H.; Hung, S.-C., From D-Glucose to Biologically Potent L-Hexoses: Synthesis of -L-Iduronidase Fluorogenic Detector and the Disaccharide Moieties of Bleomycin A2 and Heparan Sulfate, Chemistry-A European Journal, vol. 10, 399–415, 2004
2004 Kulkarni, S. S.; Chi, F.-C.; Hung, S.-C., Biologically Potent L-Hexoses and 6-Deoxy-L-hexoses: Their Syntheses and Applications, Journal of the Chinese Chemical Society, vol. 51, 1193–1200, 2004
2003 Lu, X.-A.; Chou, C.-H.; Wang, C.-C.; Hung, S.-C., Regioselective Esterification of Various D-Glucopyranosides: A Concise Synthesis of a Fully Protected Disaccharide Unit of Hyaluronic Acid, Synlett, vol. 9(S1), 1364-1366, 2003
2003 Tai, C.-A.; Kulkarni, S. S.; Hung, S.-C., Facile Cu(OTf)2-catalyzed Preparation of Per-O-acetylated Hexopyranoses with Stoichiometric Acetic Anhydride and Sequential One-pot Anomeric Substitution to Thioglycosides under Solvent-free Conditions, J. Org. Chem., vol. 68, 8719–8722, 2003
2003 Yang, W.-C.; Lu, X.-A.; Kulkarni, S. S.; Hung, S.-C., Cu(OTf)2-catalyzed Et3SiH-reductive Etherification of Various Carbonyl Compounds with Trimethylsilyl Ethers, Tetrahedron Lett., vol. 44, 7837–7840, 2003
2003 Lu, X.-A.; Chou, C.-H.; Wang, C.-C.; Hung, S.-C., Regioselective Esterification of Various D-Glucopyranosides: A Concise Synthesis of a Fully Protected Disaccharide Unit of Hyaluronic Acid, Synlett, vol. 9(S1), 1364-1366, 2003
2003 Tai, C.-A.; Kulkarni, S. S.; Hung, S.-C., Facile Cu(OTf)2-catalyzed Preparation of Per-O-acetylated Hexopyranoses with Stoichiometric Acetic Anhydride and Sequential One-pot Anomeric Substitution to Thioglycosides under Solvent-free Conditions, J. Org. Chem., vol. 68, 8719–8722, 2003
2003 Yang, W.-C.; Lu, X.-A.; Kulkarni, S. S.; Hung, S.-C., Cu(OTf)2-catalyzed Et3SiH-reductive Etherification of Various Carbonyl Compounds with Trimethylsilyl Ethers, Tetrahedron Lett., vol. 44, 7837–7840, 2003
2002 Luo, S.-Y.; Thopate, S. R.; Hsu, C.-Y.; Hung, S.-C., Synthesis of D-ribo-C18-Phytosphingosine from D-Glucosamine via the D-Allosamine Derivatives as Key Intermediates, Tetrahedron Lett., vol. 43, 4889–4892, 2002
2002 Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Fan, H.-F.; Pai, C.-L.; Yang, W.-C.; Lu, L.-D.; Hung, S.-C., Synthesis of Biologically Potent 12 Linked Disaccharide Derivatives via Regioselective One-pot Protection-glycosylation, Angewandte Chemie-International Edition, vol. 41, 2360–2362, 2002
2002 Lin, T.-S.; Chia, C.-M.; Hsiao, J.-C.; Chang, W.; Ku, C.-C.; Hung, S.-C.; Tzou, D.-L. M., Structural analysis of the extracellular domain of vaccinia virus envelope protein, A27L, by NMR and CD spectroscopy, J. Biol. Chem., vol. 277, 20949–20959, 2002
2002 Lee, J.-C.; Tai, C.-A.; Hung, S.-C., Sc(OTf)3-catalyzed Acetolysis of 1,6-Anhydro--hexopyranoses and Solvent-free Per-acetylation of Hexoses, Tetrahedron Lett., vol. 43, 851–855, 2002
2002 Wang, C.-C.; Luo, S.-Y.; Shie, C.-R.; Hung, S.-C., Metal Trifluoromethanesulfonate-Catalyzed Regioselective Borane-Reductive Ring Opening of Benzylidene Acetals: A Concise Synthesis of 1,4-Dideoxy-1,4-imino-L- xylitol, Org. Lett., vol. 4, 847–849, 2002
2002 Hung, S.-C.; Wen, Y.-F.; Chang, J.-W.; Liao, C.-C.; Uang, B.-J., A Highly Diastereoselective Synthesis of (1R)-(+)-Camphor Based Chiral Allenes and their Asymmetric Hydroboration-Oxidation Reactions, J. Org. Chem., vol. 67, 1308–1313, 2002
2002 Luo, S.-Y.; Thopate, S. R.; Hsu, C.-Y.; Hung, S.-C., Synthesis of D-ribo-C18-Phytosphingosine from D-Glucosamine via the D-Allosamine Derivatives as Key Intermediates, Tetrahedron Lett., vol. 43, 4889–4892, 2002
2002 Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Fan, H.-F.; Pai, C.-L.; Yang, W.-C.; Lu, L.-D.; Hung, S.-C., Synthesis of Biologically Potent 12 Linked Disaccharide Derivatives via Regioselective One-pot Protection-glycosylation, Angewandte Chemie-International Edition, vol. 41, 2360–2362, 2002
2002 Lin, T.-S.; Chia, C.-M.; Hsiao, J.-C.; Chang, W.; Ku, C.-C.; Hung, S.-C.; Tzou, D.-L. M., Structural analysis of the extracellular domain of vaccinia virus envelope protein, A27L, by NMR and CD spectroscopy, J. Biol. Chem., vol. 277, 20949–20959, 2002
2002 Lee, J.-C.; Tai, C.-A.; Hung, S.-C., Sc(OTf)3-catalyzed Acetolysis of 1,6-Anhydro--hexopyranoses and Solvent-free Per-acetylation of Hexoses, Tetrahedron Lett., vol. 43, 851–855, 2002
2002 Wang, C.-C.; Luo, S.-Y.; Shie, C.-R.; Hung, S.-C., Metal Trifluoromethanesulfonate-Catalyzed Regioselective Borane-Reductive Ring Opening of Benzylidene Acetals: A Concise Synthesis of 1,4-Dideoxy-1,4-imino-L- xylitol, Org. Lett., vol. 4, 847–849, 2002
2002 Hung, S.-C.; Wen, Y.-F.; Chang, J.-W.; Liao, C.-C.; Uang, B.-J., A Highly Diastereoselective Synthesis of (1R)-(+)-Camphor Based Chiral Allenes and their Asymmetric Hydroboration-Oxidation Reactions, J. Org. Chem., vol. 67, 1308–1313, 2002
2001 Hung, S.-C.; Thopate, S. R.; Puranik, R., Synthesis of 6-Deoxy-L-idose and L-Acovenose from Diacetone -D-Glucose, Carbohydrate Research, vol. 331, 369–374, 2001
2001 Hung, S.-C.; Thopate, S.-R.; Wang, C.-C., Regioselective and Stereoselective Benzoylation of 2-N-Protected 4,6-O-Ketalized D-Glucosamines with 1-(Benzoyloxy)benzotriazole, Carbohydrate Research, vol. 330, 177–182, 2001
2001 Hung, S.-C.; Thopate, S. R.; Chi, F.-C.; Chang, S.-W.; Lee, J.-C.; Wang, C.-C.; Wen, Y.-S., 1,6-Anhydro--L-hexopyranoses as Potent Synthons in the Synthesis of the Disaccharide Units of Bleomycin A2 and Heparin, J. Am. Chem. Soc., vol. 123, 3153–3154, 2001
2001 Hung, S.-C.; Wang, C.-C.; Chang, S.-W.; Chen, C-S., 1,6-Anhydro-β-l-hexopyranoses as valuable building blocks toward the synthesis of l-gulosamine and l-altrose derivatives, Tetrahedron Lett., vol. 42, 1321–1324, 2001
2001 Hung, S.-C.; Thopate, S. R.; Puranik, R., Synthesis of 6-Deoxy-L-idose and L-Acovenose from Diacetone -D-Glucose, Carbohydrate Research, vol. 331, 369–374, 2001
2001 Hung, S.-C.; Thopate, S.-R.; Wang, C.-C., Regioselective and Stereoselective Benzoylation of 2-N-Protected 4,6-O-Ketalized D-Glucosamines with 1-(Benzoyloxy)benzotriazole, Carbohydrate Research, vol. 330, 177–182, 2001
2001 Hung, S.-C.; Thopate, S. R.; Chi, F.-C.; Chang, S.-W.; Lee, J.-C.; Wang, C.-C.; Wen, Y.-S., 1,6-Anhydro--L-hexopyranoses as Potent Synthons in the Synthesis of the Disaccharide Units of Bleomycin A2 and Heparin, J. Am. Chem. Soc., vol. 123, 3153–3154, 2001
2001 Hung, S.-C.; Wang, C.-C.; Chang, S.-W.; Chen, C-S., 1,6-Anhydro-β-l-hexopyranoses as valuable building blocks toward the synthesis of l-gulosamine and l-altrose derivatives, Tetrahedron Lett., vol. 42, 1321–1324, 2001
2000 Hung, S.-C.; Puranik, R.; Chi, F.-C., Novel Synthesis of 1,2:3,5-Di-O-isopropylidene-L-idofuranoside and its Derivatives at C6, Tetrahedron Lett., vol. 41, 77–80, 2000
2000 Hung, S.-C.; Wang, C.-C.; Thopate, S. R., Efficient Synthesis of L-Altrose and L-Mannose, Tetrahedron Lett., vol. 41, 3119–3122, 2000
2000 Hung, S.-C.; Chen, C.-S., Efficient Synthesis of 1,2,3,4,6-Penta-O-acetyl-L-idopyranose, Journal of the Chinese Chemical Society, vol. 47, 1257–1262, 2000
2000 Hung, S.-C.; Puranik, R.; Chi, F.-C., Novel Synthesis of 1,2:3,5-Di-O-isopropylidene-L-idofuranoside and its Derivatives at C6, Tetrahedron Lett., vol. 41, 77–80, 2000
2000 Hung, S.-C.; Wang, C.-C.; Thopate, S. R., Efficient Synthesis of L-Altrose and L-Mannose, Tetrahedron Lett., vol. 41, 3119–3122, 2000
2000 Hung, S.-C.; Chen, C.-S., Efficient Synthesis of 1,2,3,4,6-Penta-O-acetyl-L-idopyranose, Journal of the Chinese Chemical Society, vol. 47, 1257–1262, 2000
年度 論文名稱
2017 Wei Chun Tsai, Lien Yu Hung, Teng Yi Huang, Yen Shen Shan, (Shang Cheng Hung*, Gwo Bin Lee*, A microfluidic system for detection of cholangiocarcinoma cells by using heparan sulfate octasaccharides, 2017 IEEE 12th International Conference on Nano/Micro Engineered and Molecular Systems, vol. 489-493, Apr. 09-12, 2017, Los Angeles, United States
2017 Wei Chun Tsai, Lien Yu Hung, Teng Yi Huang, Yen Shen Shan, (Shang Cheng Hung*, Gwo Bin Lee*, A microfluidic system for detection of cholangiocarcinoma cells by using heparan sulfate octasaccharides, 2017 IEEE 12th International Conference on Nano/Micro Engineered and Molecular Systems, vol. 489-493, Apr. 09-12, 2017, Los Angeles, United States
2007 Hung, S.-C., A Breakthrough for Oligosaccharide Synthesis, Natural Sciences Newsletter, vol. 19, pp.52–54-, Jan. 01, 2007, Taiwan
2007 Hung, S.-C., A Breakthrough for Oligosaccharide Synthesis, Natural Sciences Newsletter, vol. 19, pp.52–54-, Jan. 01, 2007, Taiwan
年度 書名
2016 Shang-Cheng Hung, Medel Manuel L. Zulueta, Glycochemical Synthesis: Strategies and Applications, John Wiley & Sons, Inc., 576, Jan. 2016
2016 Shang-Cheng Hung, Medel Manuel L. Zulueta, Glycochemical Synthesis: Strategies and Applications, John Wiley & Sons, Inc., 576, Jan. 2016
2015 Zulueta, M. M. L.; Hung, S.-C.*, Glycoscience: Biology and Medicine, Springer, 365-371, Jan. 2015
2015 Zulueta, M. M. L.; Hung, S.-C.*, Glycoscience: Biology and Medicine, Springer, 365-371, Jan. 2015
2011 Wang, C.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; (Hung, S.-C.*, Molecular Immunology of Complex Carbohydrates III, Springer, 691-726, Jan. 2011
2011 Wang, C.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; (Hung, S.-C.*, Molecular Immunology of Complex Carbohydrates III, Springer, 691-726, Jan. 2011

EDUCATION AND POSITIONS HELD:

  • B.S., Department of Botany, National Taiwan University, 1979
  • Ph.D., State University of New York at Buffalo, 1986
  • Postdoctoral Fellow, California Institute of Technology, 1987-1991
  • Assistant Professor, Ohio State University, 1992-1998
  • Associate Professor, Ohio State University, 1999-2006
  • Associate Professor, Genomics Research Center, Academia Sinica, 2007-2019
  • Deputy Director, Genomics Research Center, Academia Sinica, 2016-2019
  • Professor, Genomics Research Center, Academia Sinica, 2019-present
公開日期 提名
2025/07 洪上程, Hung, and S.-C.,"Breakthrough in Carbohydrate Synthesis," Newsletter NTHU, Jul. 2025
2025/07 洪上程, Chen, Z.-G.; Hu, Y.-P.; Hung, and S.-C.,"Development and Application of Flow Chemistry," Instruments Today, Jul. 2025
2023/04 洪上程, Hung, and S.-C.,"Breakthrough in Carbohydrate Synthesis," Newsletter NTHU, Apr. 2023
2023/04 洪上程, Chen, Z.-G.; Hu, Y.-P.; Hung, and S.-C.,"Development and Application of Flow Chemistry," Instruments Today, Apr. 2023