News
-
PDAC tumor cell-fibroblast interactions promote metastasis via Homophilic ATP1A1 Binding
Pancreatic ductal adenocarcinoma (PDAC) is responsible for more than 90% of pancreatic cancer cases, just 11% of PDAC patients live for at least five years after their diagnosis. It is seldom detected at its early stages when it's most curable.
-
CLEC5A and TLR2 are critical in SARS-CoV-2 induced NET formation and lung inflammation
Coronavirus-induced disease 19 (COVID‑19) infects more than 360 million patients worldwide, and people with severe symptoms frequently die of acute respiratory distress syndrome (ARDS). In severe and fatal ARDS cases, SARS-CoV-2 infection has robust pulmonary inflammation...
-
-
-
Chemists restructure an old natural product: Discovery a highly specific Golgi α-mannosidase inhibitor as a new anticancer agent
Glycoproteins play important roles in all kinds of biological events. Enzymes that were anticipated in modulation of N-glycosylation processes are regarded as a potential therapeutic target because of the key role they play in glycosylation processes. But some are undruggable because...
-
-
-
The critical point to treatment from the inside out: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment
Since James E. Rothman, Randy W. Schekman, and Thomas C. Sudhof won the Nobel Prize in 2013 for revealing intracellular vesicles’ transport regulation mechanism, such as exosomes, which initially believed the primary function was only exosomes that transport cellular waste.
-
Learning from nature: StnK3 is the epimerase controlling β-methyl amino acid stereochemistry
Natural products are a significant source of structurally diverse bioactive compounds for pharmaceutical, cosmetic, and food applications. Bioactive compounds often carry desired biological activities, such as anti-inflammation, anticancer, analgesics, and pain killing.
-
