Year	Paper Title
2022	Lee Hua-Yun, Chiang Po-Yu, Wu Hsi-Ju, Wang Ting-Yi, Yang Tzu-Ching, Cheng Wei-Chieh, Lo Lee-Chiang, Liao Wei-Ssu, Versatile Azido-Functionalized Carbon Dots for Cancer Cell Imaging, ACS Applied Nano Materials, vol. 5(9), 12374-12379, 2022
2022	Chen WA, Li HY, Sayyad A, Huang CY, Synthesis of Nitrone-derived Pyrrolidine Scaffolds and Their Combinatorial Libraries to Develop Selective alpha-l-Rhamnosidase Inhibitors., Chemistry, an Asian journal, vol. 17(14), e202200172, 2022
2022	Guo CW, Chen KT, You TY, Lin CC, Synthesis and Evaluation of Diverse N-Substituted Disaccharide Dipeptides for Human NOD2 Stimulation Activity., Chemistry, an Asian journal, vol. 17(4), e202101169, 2022
2022	Tseng YY, Liou JM, Hsu JT, Hsu TL, Wu MS, Wong CH, Combating multidrug-resistant Helicobacter pylori with moenomycin A in combination with clarithromycin or metronidazole., Frontiers in chemistry, vol. 10, 897578, 2022
2022	Chen Wei-An, Chen Yu-Hsin, Hsieh Chiao-Yun, Hung Pi-Fang, Chen Chiao-Wen, Chen Chien-Hung, Lin Jung-Lee, Cheng Ting-Jen R., Hsu Tsui-Ling, Wu Ying-Ta, Shen Chia-Ning, Cheng Wei-Chieh, Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop N-glycan modulators as anticancer agents, Chemical Science, 2022
2021	Jan JT, Cheng TR, Juang YP, Ma HH, Wu YT, Yang WB, Cheng CW, Chen X, Chou TH, Shie JJ, (Cheng WC, Chein RJ, Mao SS, Liang PH, Ma C, Hung SC, Wong CH, Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection., Proceedings of the National Academy of Sciences of the United States of America, vol. 118 (5), e2021579118, 2021
2021	Hsieh PY, Meng FC, Guo CW, Hu KH, Shih YL, Harnessing Fluorescent Moenomycin A Antibiotics for Bacterial Cell Wall Imaging Studies., Chembiochem : a European journal of chemical biology, vol. 22(24), 3462-3468, 2021
2020	Liu WJ, Hu KH, Tan YL, Lin YT, Chen WA, Lo LC, Rapid Synthesis of a Natural Product-Inspired Uridine Containing Library., ACS combinatorial science, vol. 22(11), 600-607, 2020
2020	Cheng Wei‐Chieh, You Ting‐Yun, Teo Zhen‐Zhuo, Sayyad Ashik A., Maharana Jitendra, Guo Chih‐Wei, Liang Pi‐Hui, Lin Chung‐Shun, Meng Fan‐Chun, Further Insights on Structural Modifications of Muramyl Dipeptides to Study the Human NOD2 Stimulating Activity, Chemistry – An Asian Journal, vol. 15(22), 3836-3844, 2020
2019	Chen Wei‐An, Sayyad Ashik, Chen Chiao‐Wen, Chen Yu‐Hsin, Cheng Ting‐Jen R., Cheng Wei‐Chieh, Divergent Synthesis of Bicyclic Iminosugars: Preparation of (−)‐Swainsonine‐Based Alkaloids and Their Inhibition Study towards α ‐Human Mannosidases, Asian Journal of Organic Chemistry, vol. 8(12), 2233-2242, 2019
2018	Li HY, Lee JD, Chen CW, Sun YC, Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines., European journal of medicinal chemistry, vol. 144, 626-634, 2018
2018	Wu WS, Cheng TR, Wong CH, Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase., Journal of the American Chemical Society, vol. 140(8), 2752-2755, 2018
2018	Lin CK, Li HY, Chang YC, Lu SJ, Chen YS, Chang SY, A combinatorial approach towards the synthesis of non-hydrolysable triazole-iduronic acid hybrid inhibitors of human alpha-l-iduronidase: discovery of enzyme stabilizers for the potential treatment of MPSI., CHEMICAL COMMUNICATIONS, vol. 54(21), 2647-2650, 2018
2017	Wang JH, Yun WY, Li HY, Hu JM, Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries to discover a pharmacological chaperone for treatment of Fabry disease., European journal of medicinal chemistry, vol. 126, 1-6, 2017
2017	Chen KT, Lin CK, Guo CW, Chang YF, Hu CM, Lin HH, Lai Y, Cheng TR, Effect of the lipid II sugar moiety on bacterial transglycosylase: the 4-hydroxy epimer of lipid II is a TGase inhibitor., CHEMICAL COMMUNICATIONS, vol. 53(4), 771-774, 2017
2016	Chen KT, Chen PT, Lin CK, Huang LY, Hu CM, Chang YF, Hsu HT, Cheng TJ, Wu YT, Structural Investigation of Park's Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors., Scientific reports, vol. 6, 31579, 2016
2016	Lin CK, Hou CC, Guo YY, Design and Synthesis of Orthogonally Protected d- and l-beta-Hydroxyenduracididines from d-lyxono-1,4-Lactone., Organic letters, vol. 18(20), 5216-5219, 2016
2016	Wang JH, Li HY, Lu SJ, Hu JM, Yun WY, Chiu CH, Yang WB, Chien YH, Hwu WL, Bioevaluation of sixteen ADMDP stereoisomers toward alpha-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency., European journal of medicinal chemistry, vol. 123, 14-20, 2016
2016	Lin CK, Yun WY, Lin LT, A concise approach to the synthesis of the unique N-mannosyl d-beta-hydroxyenduracididine moiety in the mannopeptimycin series of natural products., Organic & biomolecular chemistry, vol. 14(17), 4054-4060, 2016
2015	Lin CK, Cheng LW, Li HY, Yun WY, Synthesis of novel polyhydroxylated pyrrolidine-triazole/-isoxazole hybrid molecules., Organic & biomolecular chemistry, vol. 13(7), 2100-2107, 2015
2015	Chen KT, Huang DY, Chiu CH, Lin WW, Liang PH, Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity., Chemistry-A European Journal, vol. 21(34), 11984-11988, 2015
2015	Lin CK, Chen KT, Hu CM, Yun WY, Synthesis of 1-C-Glycoside-Linked Lipid II Analogues Toward Bacterial Transglycosylase Inhibition., Chemistry-A European Journal, vol. 21(20), 7511-7519, 2015
2015	Guo CW, Lin CK, Jiang YR, Synthesis and Inhibition Study of Bicyclic Iminosugar-​Based Alkaloids, Scaffolds, and Libraries towards Glucosidase, Israel Journal of Chemistry, vol. 55(3-4), 403-411, 2015
2015	Chen PT, Lin CK, Tsai CJ, Huang DY, Nien FY, Lin WW, Expeditious Synthesis of Enantiopure, Orthogonally Protected Bis-alpha-Amino Acids (OPBAAs) and their Use in a Study of Nod1 Stimulation., Chemistry-An Asian Journal, vol. 10(2), 474-482, 2015
2015	Zuegg J, Muldoon C, Adamson G, McKeveney D, Le Thanh G, Premraj R, Becker B, Cheng M, Elliott AG, Huang JX, Butler MS, Bajaj M, Seifert J, Singh L, Galley NF, Roper DI, Lloyd AJ, Dowson CG, Cheng TJ, Demon D, Meyer E, Meutermans W, Cooper MA, Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity., Nature communications, vol. 6, 7719, 2015
2014	Hsu CH, Schelwies M, Enck S, Huang LY, Huang SH, Chang YF, Cheng TJ, Wong CH, Iminosugar C-Glycoside Analogues of alpha-d-GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase Inhibition., The Journal of organic chemistry, vol. 79(18), 8629-8637, 2014
2014	Huang LY, Huang SH, Chang YC, Cheng TJ, Wong CH, Enzymatic Synthesis of Lipid II and Analogues., Angewandte Chemie-International Edition, vol. 53(31), 8060-8065, 2014
2014	Tseng YY, Liou JM, Hsu TL, Wu MS, Wong CH, Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori., Bioorganic & medicinal chemistry letters, vol. 24(11), 2412-2414, 2014
2013	Pan YW, Guo CW, Tu HY, Tsai CW, Solid-Phase Synthesis of Diverse Spiroisoxazolinodiketopiperazines., ACS combinatorial science, vol. 15(8), 425-434, 2013
2013	Chen KT, Kuan YC, Fu WC, Liang PH, Cheng TJ, Wong CH, Rapid preparation of mycobacterium N-glycolyl Lipid I and Lipid II derivatives: a biocatalytic approach., Chemistry-a European Journal, vol. 19(3), 834-838, 2013
2013	Weng CY, Yun WY, Chang SY, Lin YC, Tsai FJ, Huang FY, Chen YR, Rapid modifications of N-substitution in iminosugars: development of new beta-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease., Bioorganic & medicinal chemistry, vol. 21(17), 5021-5028, 2013
2013	Huang SH, Wu WS, Huang LY, Huang WF, Fu WC, Chen PT, Fang JM, Cheng TJ, Wong CH, New continuous fluorometric assay for bacterial transglycosylase using Forster resonance energy transfer., Journal of the American Chemical Society, vol. 135(45), 17078-17089, 2013
2013	Cheng TJ, Chan TH, Tsou EL, Chang SY, Yun WY, Yang PJ, Wu YT, From Natural Product-Inspired Pyrrolidine Scaffolds to the Development of New Human Golgi alpha-Mannosidase II Inhibitors., Chemistry-An Asian Journal, vol. 8(11), 2600-2604, 2013
2012	Hsu YC, Chen NC, Chen PC, Wang CC, Wu HN, Identification of a small-molecule inhibitor of dengue virus using a replicon system., Archives of virology, vol. 157(4), 681-688, 2012
2012	Shih HW, Chang YF, Li WJ, Meng FC, Huang CY, Ma C, Cheng TJ, Wong CH, Effect of the Peptide Moiety of Lipid II on Bacterial Transglycosylase., Angewandte Chemie-International Edition, vol. 51(40), 10123-10126, 2012
2012	Huang CY, Shih HW, Lin LY, Tien YW, Cheng TJ, Wong CH, Ma C, Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism., Proceedings of the National Academy of Sciences of the United States of America, vol. 109(17), 6496-6501, 2012
2012	Hao-Wei Shih, Kuo-Ting Chen, Wei-Chieh Cheng*, One-pot synthesis of phosphate diesters and phosphonate monoesters via a combination of microwave-CCl3CN-pyridine coupling conditions, Tetrahedron Lett., vol. 53(2), 243-246, 2012
2011	Meng FC, Chen KT, Huang LY, Shih HW, Chang HH, Nien FY, Liang PH, Cheng TJ, Wong CH, Total Synthesis of Polyprenyl N-Glycolyl Lipid II as a Mycobacterial Transglycosylase Substrate., Org. Lett., vol. 13(19), 5306-5309, 2011
2011	Chang YF, Guo CW, Chan TH, Pan YW, Tsou EL, Parallel synthesis of natural product-like polyhydroxylated pyrrolidine and piperidine alkaloids., Molecular diversity, vol. 15(1), 203-214, 2011
2011	Shih HW, Chen KT, Cheng TJ, Wong CH, A New Synthetic Approach toward Bacterial Transglycosylase Substrates, Lipid II and Lipid IV., Org. Lett., vol. 13(17), 4600-4603, 2011
2010	Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Wu YT, Tsai MD, Cheng YS, Wong CH, High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity., Proceedings of the National Academy of Sciences of the United States of America, vol. 107(45), 19151-19156, 2010
2010	Cheng TJ, Wu YT, Yang ST, Lo KH, Chen SK, Chen YH, Huang WI, Yuan CH, Guo CW, Huang LY, Chen KT, Shih HW, Cheng YS, Wong CH, High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase., Bioorganic & medicinal chemistry, vol. 18(24), 8512-8529, 2010
2010	Shih HW, Chen KT, Chen SK, Huang CY, Cheng TJ, Ma C, Wong CH, Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors., Organic & biomolecular chemistry, vol. 8(11), 2586-2593, 2010
2010	Chen-Yu Liu, Chih-Wei Guo, Yi-Fan Chang, Jen-Tsung Wang, Hao-Wei Shih, Yu-Fang Hsu, Chia-Wei Chen, Shao-Kang Chen, Yen-Chih Wang, Ting-Jen R. Cheng, Che Ma, Chi-Huey Wong, Jim-Min Fang*, Wei-Chieh Cheng)*, Synthesis and Evaluation of a New Fluorescent Transglycosylase Substrate: Lipid II-Based Molecule Possessing a Dansyl-C20 Polyprenyl Moiety, Org. Lett., vol. 12(7), 1608-1611., 2010
2010	Tin-Hao Chan, Yi-Fan Chang, Jung-Jung Hsu, Wei-Chieh Cheng, Straightforward Synthesis of Diverse 1-Deoxyazapyranosides via Stereocontrolled Nucleophilic Additons to Six-Membered Cyclic Nitrones, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2010(59), 5555-5559, 2010
2009	Shih, Hao-Wei, Guo, Chih-Wei, Lo, Kien-Hock, Huang, Min-Yang, Cheng, Wei-Chieh*, Solution-Phase Parallel Synthesis of Novel Spirooxazolinoisoxazolines, Journal of Combinatorial Chemistry, vol. 11(2), 281-287, 2009
2009	Tsou, En-Lun, Yeh, Yao-Ting, Liang, Pi-Hui, Cheng, Wei-Chieh*, A convenient approach toward the synthesis of enantiopure isomers of DMDP and ADMDP, Tetrahedron, vol. 65(1), 93-100, 2009
2009	Sung, M. T. Lai, Y. T. Huang, C. Y. Chou, L. Y. Shih, H. W. Cheng, W. C. Wong, C. H. Ma, C., Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 106(22), 8824-8829, 2009
2008	Chang, Yi-Fan, Jiang, Yi-Rui, Cheng, Wei-Chieh*, Traceless sulfone linker cleavage triggered by ozonolysis: solid-phase synthesis of diverse alpha -beta -unsaturated carbonyl compounds, Tetrahedron Lett., vol. 49(3), 543-547., 2008
2008	Tsou EL, Chen SY, Yang MH, Wang SC, Cheng TR, Synthesis and biological evaluation of a 2-aryl polyhydroxylated pyrrolidine alkaloid-based library., Bioorganic & medicinal chemistry, vol. 16(24), 10198-204, 2008
2008	Huang, Chih-Ming, Liu, Rai-Shung, Wu, Tian-Shung, Cheng, Wei-Chieh*, Structural establishment of polygalatenosides A and B by total synthesis, Tetrahedron Lett., vol. 49(18), 2895-2898, 2008
2008	Shih, Hao-Wei, Cheng, Wei-Chieh*, Solution-phase parallel synthesis of highly diverse spiroisoxazolinohydantoins, Tetrahedron Lett., vol. 49(6), 1008-1011, 2008
2008	Chang, Yi-Fan, Liu, Chen-Yu, Guo, Chih-Wei, Wang, Yen-Chih, Fang, Jim-Min, Cheng, Wei-Chieh*, Solid-Phase Organic Synthesis of Polyisoprenoid Alcohols with Traceless Sulfone Linker, J. Org. Chem., vol. 73(18), 7197-7203, 2008
2008	Cheng TJ, Sung MT, Liao HY, Chang YF, Chen CW, Huang CY, Chou LY, Wu YD, Chen YH, Cheng YS, Wong CH, Ma C, Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105(2), 431-6, 2008

Year	Paper Title
2008	Shirley, Morgan E., Cheng, Wei-Chieh, Synthesis of new polyhydroxylated pyrrolidine alkaloids and their future as biological inhibitors, 235th ACS National Meeting, New Orleans, LA, United States, vol. MEDI-306, Apr. 06-10, 2008, Department of Biochemistry, IREU,Texas A&M,Overland Park,KS,USA.